SynLeGG is free of charge for all to use (including for commercial use). We make every effort to ensure that the software is free from errors, however all usage of SynLeGG implies acceptance of the disclaimer notice. Usage of SynLeGG also implies acceptance of these Terms of Use and the Privacy & Cookie Policy. If you use SynLeGG in any published academic or commercial materials, please cite:
Wappett M, Harris A, Lubbock ALR, Lobb I, McDade S, Overton IM (2021). SynLeGG: analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships. Nucleic Acids Research doi: doi.org/10.1093/nar/gkab338
DepMap, Broad (2020): DepMap 20Q3 Public. figshare. Dataset doi:10.6084/m9.figshare.12931238.v1.
Robin M. Meyers, Jordan G. Bryan, James M. McFarland, Barbara A. Weir, ... David E. Root, William C. Hahn, Aviad Tsherniak. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics 2017 October 49:1779-1784. doi:10.1038/ng.3984
Dempster, J. M., Rossen, J., Kazachkova, M., Pan, J., Kugener, G., Root, D. E., & Tsherniak, A. (2019). Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines. BioRxiv, 720243.
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, ... Todd R. Golub, Levi A. Garraway & William R. Sellers. 2019. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569, 503-508 (2019).
Also please see the depmap terms and the CC Attribution 4.0 (CC BY) license. We hope you find SynLeGG a useful research tool. We are always keen to hear feedback and comments. Please contact us with your views, they are much appreciated.
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